SHISEIDO

Corporate Policy on Animal Testing and Alternative Methods

Shiseido's Policy towards Abolishing Animal Testing for Cosmetics

Shiseido does not test its cosmetic products on animals, under any circumstances. As for cosmetic ingredients, we do not conduct animal testing save for exceptional cases where it is required by law, or where there are absolutely no other alternative methods to animal testing, and therefore unavoidable to guarantee product safety *1 .

Shiseido's goal is to eliminate "animal testing" for cosmetics, rigorously working to ensure the safety of cosmetics, in order that our customers can feel safe to use them, while paying full respect to animal protection as well.

Shiseido shall proactively seek the abolition of animal testing in line with EU regulations (the EU's Cosmetics Directive) *2 , which envisions to eliminate animal testing by 2013.

Up until its abolition in 2013, we will, through collaboration with domestic and international industry groups and institutions working to verify alternative methods, such as the Japan Cosmetic Industry Association, the European Centre for the Validation of Alternative Methods and the U.S.'s Interagency Coordinating Committee on the Validation of Alternative Methods, continue to exert our utmost efforts on developing alternative methods *3 that would enable us to eliminate animal testing at the earliest possible opportunity.

Year SHISEIDO's Studies contributing to development of alternative methods and safety evaluation
2008 Study on a tier evaluation system for eye irritation test using monolayer culture of SIRC cells and a three-dimensional dermal model
2005 A Japanese ring study of human Cell Line Activation Test (h-CLAT) for predicting skin sensitizing potential of chemicals in vitro
Studies on the effects of light sources used in alternative methods for phototoxicity testing
2003 Studies on the use of culture cell lines as alternative methods for acute toxicity testing
2002 Research on the development of a predictive algorithm for skin permeability and its use for predicting skin sensitizing potential of chemicals
2001 Studies on the use of CD86 and MHC class II expression in THP-1 human monocytes as an index of an alternative method for skin sensitization tests
2000 Studies on the induction of unscheduled DNA synthesis in epidermis by skin carcinogens
1999 Comparative study on the neutral red uptake phototoxicity methods in three different cell lines
1997 Studies on the use of cytotoxicity assays as an alternative alternative method for skin irritation test for evaluating the irritant properties of water-insoluble chemicals
1996 Studies on the use of quantitative measurements of pro-inflammatory cytokine gene expression as an alternative method for skin irritation test
1994 Studies on the application of electrophysiological techniques on neuronal cells for use as an in vitro skin sensory irritation test
1992 Studies on the use of red blood cells photohemolysis and yeast growth inhibition assays as alternative methods for phototoxicity tests
1991 Study on the use of hemoglobin denaturation assay as an alternative method for eye irritation tests
Study on the use of liposomes prepared from lipids extracts of bovine cornea, as an alternative method for eye irritation test

Above studies were awarded by various organizations such as the Japanese Society for Alternatives to Animal Experiments.

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